Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial (2024)

Kaiser, C., Kehrer, C., Keyver-Paik, M. D., Hecking, T., Ayub, T. H., Leutner, C., Schild, H. (2017). Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial. Hormone Molecular Biology and Clinical Investigation, 32(1), Article 20170041. https://doi.org/10.1515/hmbci-2017-0041

Kaiser, Christina ; Kehrer, Christina ; Keyver-Paik, Mignon Denise et al. / Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial. In: Hormone Molecular Biology and Clinical Investigation. 2017 ; Vol. 32, No. 1.

@article{1a9d8d695de04ea5937d214b95f6ddfa,

title = "Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial",

abstract = "A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies. Therefore, MRI in preoperative imaging remains controversial. To validate our retrospective data we initiate a prospective one-armed multicenter trial for patients with histologically confirmed breast cancer performing routine imaging by ultrasound and mammography followed by MRI imaging based on menopause status, histologic subtype, ACR and Breast Imaging Reporting and Data System (BIRADS)-classification. Primary endpoint is the rate of additional findings and change of treatment strategy, secondary endpoints are local recurrence-free, distant recurrence-free and overall survival. Additional MRI findings are calculated to be above 10% with a number of 100 patients recruited and a power of 80%. MRI is detecting more tumor foci than conventional imaging but remains controversial in primary breast cancer for preoperative imaging because of the fear of over-diagnosis and the increased morbidity of additional potentially unnecessary surgical procedures. This planned one-armed prospective multicenter trial is designed to confirm our retrospectively revealed data defining subgroups with significant benefit of preoperative MRI to come to a consensus avoiding over-diagnosis and false-positive results leading to clinically beneficial and cost-effective use of preoperative MRI.",

keywords = "breast cancer, breast imaging, MRI, premenopausal, preoperative management, prospective trial",

author = "Christina Kaiser and Christina Kehrer and Keyver-Paik, {Mignon Denise} and Thomas Hecking and Ayub, {Tiyasha Hosne} and Claudia Leutner and Hans Schild and Walther Kuhn",

note = "Publisher Copyright: {\textcopyright} 2017 2017 Walter de Gruyter GmbH, Berlin/Boston.",

year = "2017",

month = oct,

day = "26",

doi = "10.1515/hmbci-2017-0041",

language = "English",

volume = "32",

journal = "Hormone Molecular Biology and Clinical Investigation",

issn = "1868-1883",

publisher = "Walter de Gruyter GmbH",

number = "1",

}

Kaiser, C, Kehrer, C, Keyver-Paik, MD, Hecking, T, Ayub, TH, Leutner, C, Schild, H 2017, 'Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial', Hormone Molecular Biology and Clinical Investigation, vol. 32, no. 1, 20170041. https://doi.org/10.1515/hmbci-2017-0041

Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial. / Kaiser, Christina; Kehrer, Christina; Keyver-Paik, Mignon Denise et al.
In: Hormone Molecular Biology and Clinical Investigation, Vol. 32, No. 1, 20170041, 26.10.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial

AU - Kaiser, Christina

AU - Kehrer, Christina

AU - Keyver-Paik, Mignon Denise

AU - Hecking, Thomas

AU - Ayub, Tiyasha Hosne

AU - Leutner, Claudia

AU - Schild, Hans

AU - Kuhn, Walther

N1 - Publisher Copyright:© 2017 2017 Walter de Gruyter GmbH, Berlin/Boston.

PY - 2017/10/26

Y1 - 2017/10/26

N2 - A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies. Therefore, MRI in preoperative imaging remains controversial. To validate our retrospective data we initiate a prospective one-armed multicenter trial for patients with histologically confirmed breast cancer performing routine imaging by ultrasound and mammography followed by MRI imaging based on menopause status, histologic subtype, ACR and Breast Imaging Reporting and Data System (BIRADS)-classification. Primary endpoint is the rate of additional findings and change of treatment strategy, secondary endpoints are local recurrence-free, distant recurrence-free and overall survival. Additional MRI findings are calculated to be above 10% with a number of 100 patients recruited and a power of 80%. MRI is detecting more tumor foci than conventional imaging but remains controversial in primary breast cancer for preoperative imaging because of the fear of over-diagnosis and the increased morbidity of additional potentially unnecessary surgical procedures. This planned one-armed prospective multicenter trial is designed to confirm our retrospectively revealed data defining subgroups with significant benefit of preoperative MRI to come to a consensus avoiding over-diagnosis and false-positive results leading to clinically beneficial and cost-effective use of preoperative MRI.

AB - A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies. Therefore, MRI in preoperative imaging remains controversial. To validate our retrospective data we initiate a prospective one-armed multicenter trial for patients with histologically confirmed breast cancer performing routine imaging by ultrasound and mammography followed by MRI imaging based on menopause status, histologic subtype, ACR and Breast Imaging Reporting and Data System (BIRADS)-classification. Primary endpoint is the rate of additional findings and change of treatment strategy, secondary endpoints are local recurrence-free, distant recurrence-free and overall survival. Additional MRI findings are calculated to be above 10% with a number of 100 patients recruited and a power of 80%. MRI is detecting more tumor foci than conventional imaging but remains controversial in primary breast cancer for preoperative imaging because of the fear of over-diagnosis and the increased morbidity of additional potentially unnecessary surgical procedures. This planned one-armed prospective multicenter trial is designed to confirm our retrospectively revealed data defining subgroups with significant benefit of preoperative MRI to come to a consensus avoiding over-diagnosis and false-positive results leading to clinically beneficial and cost-effective use of preoperative MRI.

KW - breast cancer

KW - breast imaging

KW - MRI

KW - premenopausal

KW - preoperative management

KW - prospective trial

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U2 - 10.1515/hmbci-2017-0041

DO - 10.1515/hmbci-2017-0041

M3 - Article

C2 - 29127760

AN - SCOPUS:85039447655

SN - 1868-1883

VL - 32

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

IS - 1

M1 - 20170041

ER -

Kaiser C, Kehrer C, Keyver-Paik MD, Hecking T, Ayub TH, Leutner C et al. Preoperative breast MRI-examination for all patients with histologically proven breast cancer? A concept for a prospective multicenter trial. Hormone Molecular Biology and Clinical Investigation. 2017 Oct 26;32(1):20170041. doi: 10.1515/hmbci-2017-0041